Azithromycin Dosage: Simple Rules for Safe Use

If you’ve been prescribed azithromycin, you probably wonder how much to take and for how long. The good news is the drug comes in a few standard schedules that cover most infections. Below you’ll find the most common adult and pediatric doses, special‑case adjustments, and safety pointers you can start using right away.

Typical adult dosing

For most bacterial infections – like bronchitis, sinusitis, or strep throat – the usual adult plan is a 500 mg tablet on day 1, followed by 250 mg once daily on days 2‑5. This “single‑big‑dose then smaller daily doses” routine lets the medicine stay in your system long enough to finish the infection without a daily pill burden.

If you’re treating a more serious infection (e.g., pneumonia) the doctor may order 500 mg daily for three days straight. In any case, finish the full course even if you feel better after a couple of days. Stopping early can let bacteria survive and become resistant.

Kids and weight‑based dosing

Children don’t get a flat 500 mg dose. Instead, doctors calculate it by weight: 10 mg per kilogram of body weight on day 1, then 5 mg/kg once daily for the next four days. For example, a child who weighs 20 kg would take 200 mg on the first day and 100 mg each day thereafter.

Liquid azithromycin (often 200 mg/5 ml) makes it easy to measure the right amount. Use the dose‑measuring syringe that comes with the bottle – a kitchen teaspoon can be off by a lot.

Special situations and tips

People with liver problems may need a lower total dose because azithromycin is processed there. Your doctor might cut the dose in half or spread it over a longer period. Same goes for severe kidney disease; the drug hangs around longer, so dose adjustments help avoid side effects.

Taking azithromycin with food isn’t required, but a light snack can calm a mild stomach upset some folks feel. Avoid antacids that contain aluminum or magnesium within two hours of the dose, as they can lower the drug’s absorption.

What to watch for

Most users tolerate azithromycin well. The most common side effects are mild nausea, diarrhea, or a vague headache. If you notice a fast heartbeat, severe rash, or breathing trouble, stop the medication and call a doctor right away – these could be signs of a rare allergic reaction.

Because azithromycin can affect the heart’s rhythm, anyone with a history of irregular heartbeat or who’s on other QT‑prolonging drugs should discuss risks with their prescriber.

Finally, don’t share leftovers or use old pills for a new infection. Even if the symptoms seem similar, the bacteria causing the new illness might need a different antibiotic.

Stick to the schedule your doctor gave you, finish the whole pack, and keep these safety tips in mind. With the right dose, azithromycin is a powerful ally against many common infections.

Alan Gervasi 0 21 Sep 2025

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